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课题组长期招聘具有药理学、药物化学、化学生物学等学科背景的研究人员，可提供副教授、讲师、博士后，助理研究员等职位。

工作经历

11/2018-至今：苏州大学，bat365中文官方网站，药物化学系主任 (2023)，特聘教授

12/2014-10/2018：Research Scientist, 佐治亚州立大学化学系

12/2013-12/2014: 博士后，佐治亚州立大学化学系

 09/2011-12/2013: 助理研究员，北京协和医学院医药生物技术研究所

本科& 硕士(9/2002 – 7/2008)

北京科技大学应用学院，应用化学/分析化学

博士 (9/2008 – 7/2011)

北京协和医学院医药生物技术研究所, 微生物与生化药学

研究兴趣

• 气体信使小分子（CO, H₂S等）药物化学生物学研究：发展新颖的脱笼（decaging）化学，用于气体信使小分子的可控靶向递送，并研究其在相关重大疾病的发生、发展以及治疗方面的作用。

• 新型Click化学的发现及其相关化学生物学研究：发展新颖的Click反应，并用于相关化学生物学研究，包括生物正交前药的设计，生物大分子的可逆可视化标记等。

• 抗感染、抗肿瘤靶向小分子药物的设计合成：基于传统药物化学策略，进行抗感染、抗肿瘤小分子靶向药物的设计与合成。

研究课题

1. 2022-2024，江苏省特聘教授特别资助，200万，项目负责人.

2. 2023-2026，国家自然科学基金面上项目，54万，项目负责人.

3. 2019-2022，江苏省六大人才高峰，4万，项目负责人.

4.   2017-2020，中国医学科学院医学与健康科技创新工程，160万元，项目负责人.

5.  2018-2021， 国家自然科学基金面上项目（81773608），58.5 万元，项目负责人.

6.  2015-2017，国家自然科学基金青年项目 (81402827)， 23万元，项目负责人.

代表性论文（Since 2020）

1. Zhicheng Yan, Yiyao Pan, Guofeng Jiao, Mengyu Xu, Dongguang Fan, Ziwei Hu, Jiarui Wu, Tao Chen, Miao Liu, Xiaoguang Bao*, Hengte Ke*, andXingyue Ji*. A Bioorthogonal Decaging Chemistry of N-Oxide and Silylborane for Prodrug Activation both In Vitro and In Vivo. J. Am. Chem. Soc.2023, 145, 45, 24698–24706. (ACS Editors’ Choice)

2. Zhang Li, Yongming Wang, Miao Liu, Yiyao Pan, Zihui Ni, Qingqiang Min, Binghe Wang*, Hengte Ke*, and Xingyue Ji*. Reactive Oxygen Species-Activated Metal-Free Carbon Monoxide Prodrugs for Targeted Cancer Treatment. J. Med. Chem., 2023, 66, 14583–14596.

3. Qingqiang Min and Xingyue Ji*. Bioorthogonal Bond Cleavage Chemistry for On-demand Prodrug Activation: Opportunities and Challenges. J. Med. Chem. 2023, 66(24):16546-16567.

4. Shengchao Zhou, Kun Wang, Ziwei Hu, Tao Chen, Yao Dong, Rongmei Gao, Mengyuan Wu, Yuhuan Li, Xingyue Ji*. Design, synthesis, and structure-activity relationships of a novel class of quinazoline derivatives as coronavirus inhibitors. Eur. J. Med. Chem., 2023, 161, 115831.

5. Miao Liu, Zhang Li, Ziwei Hu, ZhiCheng Yan, Qingqiang Min, Wei Peng* and Xingyue Ji*. Dichloromethanol but not difluoromethanol as a viable surrogate of carbon monoxide for prodrug design. Chem. Commun., 2023, 59, 5583.

6. Ru Dong, Xiaoxiao Yang, Binghe Wang,* Xingyue Ji*. Mutual leveraging of proximity effects and click chemistry in chemical biology. Med. Res. Rev.2023, doi:10.1002/med.21927. (IF: 12.3)

7. Qingqiang Min, Xingyue Ji.* Strategies toward Metal-Free Carbon Monoxide Prodrugs: An Update. ChemMedChem, 2023, 18(1): e202200500. (Invited review) (IF: 3.5)

8. Miao Liu, Yuhan Wang, Zhicheng Yan, Jiabin Yang, Yongyou Wu*, Dawei Ding*, Xingyue Ji*. Photoclick and Release: Co-activation of Carbon Monoxide and a Fluorescent Self-reporter, COS or Sulfonamide with Fast Kinetics. ChemBioChem,2023, 24(3):e202200506. (IF: 3.5).

9. Zhou Zhou, Shun Feng, Jujun Zhou, Xingyue Ji*, Ya-Qiu Long*. On-Demand Activation of a Bioorthogonal Prodrug of SN-38 with Fast Reaction Kinetics and High Releasing Efficiency In Vivo. J. Med. Chem.2022, 65(1):333-342. (IF: 8.0)

10. Qingqiang Min,^# Zihui Ni,^# Meng You, Miao Liu, Zhou Zhou, Hengte Ke*, Xingyue Ji*. Chemiexcitation-Triggered Prodrug Activation for Targeted Carbon Monoxide Delivery. Angew. Chem. Int. Ed.2022, 61, e202200974. (IF: 16.3)

11. Xingyue Ji*, Zhiyuan Zhong*. External stimuli-responsive gasotransmitter prodrugs: Chemistry and spatiotemporal release. J. Control. Release. 2022, 351, 81-101. (IF: 11.0)

12. Xingyue Ji*, Zhuo-Rong Li*. Medicinal chemistry strategies toward host targeting antiviral agents. Med. Res. Rev.2020, 40, 1519-1557. (IF: 12.3)

13. Shengchao Zhou, Yujie Mou, Miao Liu, Qian Du, Basharat Ali, Jurupula Ramprasad, Chunhua Qiao, Li-Fang Hu*, Xingyue Ji*. Insights into the Mechanism of Thiol Triggered COS/H2S Release from N-Dithiasuccinoyl Amines. J. Org. Chem.2020, 85(13):8352-8359. (IF: 4.3)